2. Can a rushing attack keep rolling?

Detroit’s passing attack hasn’t quite been clicking on all cylinders this season, despite ranking seventh in the NFL in passing going into tonight’s game. However, Detroit’s ground game has increased to 163 rushing yards per game through the first three weeks of the season and is coming off a 188 yards on the ground performance in last week’s win over Arizona. Detroit gained at least 4.0 yards on 53 of their 101 rushing attempts this season, the third-best mark in the league.

Seattle ranks 15th in the NFL against the run, allowing 116 yards on the ground per game. The Lions are at their best offensively when they can dictate the tempo with their run game and use the passing attack as a complement. See if they can put the run together early and often tonight.

3. Replace defensive starters

Detroit lost defensive end Marcus Davenport for the remainder of the season and SAM linebacker Derrick Barnes for the foreseeable future. Davenport has been a productive player for a Lions defense that ranks second in the NFL in QB hits (15) and top 10 in total pressures (57) through the first three weeks. Third-year defensive lineman Josh Paschal is expected to get the bulk of the snaps in Davenport’s absence, although the Lions have options to rotate several players opposite Aidan Hutchinson. It’s important that the Lions get production from that spot, otherwise teams will use more and more resources to slow down Hutchinson on the other end.

As for replacing Barnes, Glenn said he has a lot of confidence in the depth at linebacker, probably more than any other position group on his defense.

“We have a number of guys in that linebacker room that would like to play that role,” Glenn said this week. “And I’ve said this every week, that’s a room that I have a lot of respect for the way they work. I have a lot of respect for the friendship and the closeness that they have in that room, and I have a lot of respect for the versatility we have in that room.”