The Northwestern Wildcats look to extend one streak and end another when they host the Duke Blue Devils at Northwestern Medicine Field at Martin Stadium in Evanston, Ill. on Friday. Northwestern (1-0) opened its 2024 campaign with its fifth straight win since last season, a 13-6 home victory over Miami (OH). However, the Wildcats have lost their last five meetings with Duke and are 13-10 in the all-time series. The Blue Devils (1-0) are looking for their third straight 2-0 start to a season after beating Elon 26-3 in their opener.

Kickoff is scheduled for 9:00 p.m. ET. The Wildcats are 1.5-point favorites in the latest SportsLine consensus Northwestern vs. Duke odds, while the over/under for total points scored is 37. Before you make any Duke vs. Northwestern picks or CFB predictions, you should see what the SportsLine Projection Model has to say.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It also comes from a profitable 13-9 season on top-rated spread picks. Anyone who has followed has seen STRONG returns!

The model notes that Northwestern has won three straight non-conference games for the first time since 2016-17 and is looking for its first six-game winning streak since 2019-20. Quarterback Mike Wright led the Wildcats offensively in their season-opening win, completing 18 of 30 pass attempts for 178 yards while rushing for a team-high 65 yards and their lone touchdown. The defense played a key role in the win, limiting Miami (OH) to 40 yards on the ground while recording four sacks and two interceptions as Northwestern went without a TD for the first time since their 2020 season opener against Maryland.

The model also factored in the fact that Duke also had a strong defensive effort in its first game of the year. The Blue Devils allowed just 140 total yards, including 30 rushing, while registering eight sacks and 16 tackles for loss against Elon. Quarterback Maalik Murphy threw for 291 yards and a pair of touchdowns in his Duke debut after transferring from Texas, while wideout Jordan Moore hauled in seven passes for 112 yards.

The model has simulated Northwestern versus Duke 10,000 times and the results are in. We can tell you that the model is tilted towards the total, and it also says that one side of the spread hits over 60% of the time!

Who wins Duke vs. Northwest, and which side of the spread is reached in over 60% of the cases? … Join SportsLine now and find out which side of the spread you should be on, from the 13-9 roll model to the top-rated CFB picks!