49ers vs. Patriots 2024 Prediction, Odds, Experts’ Picks

The San Francisco 49ers (1-2) are considered favorites (-10.5) according to bookmakers ahead of their match against the New England Patriots (1-2) on September 29, 2024, starting at 4:05 PM ET, broadcast on FOX. The matchup has an over/under of 40.5 points.

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Betting information for 49ers vs Patriots updated on September 27, 2024, 2:34 PM ET.
Favorite	Spread	Favorite spread odds	Underdog spread odds	Total	More than total opportunity	Under Total Odds
49ers	-10.5	-108	-112	40.5	-112	-108

49ers vs. Patriots Prediction and Picks

Choose ATS: Choose Em
Choose OE: Below (40.5)
Prediction: 49ers 25 – Patriots 15

How to watch San Francisco vs. New England

Game date: Sunday September 29, 2024
Time: 4:05 PM ET
Location: Levi’s Stadium
Location: Santa Clara, California
TV: Watch on FOX
Live Box Score: FOX Sports

Pick by FOX Sports Betting Analyst Chris Fallica:

Last week’s loss to the Rams was devastating and inexcusable for the Niners, despite all the injuries. Building a two-win lead against a team with as many key injuries as the Rams just can’t happen. Luckily, the Niners get one of the worst teams in the league at home as a chance to get even. The Patriots O-Line against the Jets was downright awful and I don’t see it getting much better here. SF gets up early and gets a great win.

PICK: 49ers (-10.5) to win by more than 10.5 points

49ers vs. Patriots Recent Matchups

In their last four meetings, New England has three wins against San Francisco.
San Francisco has been outscored by 29 points in its last four games against New England.

San Francisco betting information

This year, San Francisco has one win against the spread.
San Francisco games have eclipsed the over/under twice in three chances this year (66.7%).
When playing as the moneyline favorite, the 49ers are 1-2 and get a win 33.3% of the time.
Looking at the money line of this game, the 49ers’ implied probability of winning is 85.7%.

49ers stats

Stands	Average (total)	Rank
Pass yards	267.7 (803)	1
Urgent yards	139.7 (419)	10
Points scored	24.3 (73)	9
Pass yards against	217.7 (653)	20
Urgent meters against	104.0 (312)	9
Points allowed	23.0 (69)	21

San Francisco’s key players

Offence

Brock Purdy ranks third in the NFL with 842 passing yards through three games this year, averaging 280.7 per game with a 72.6% completion percentage and four touchdowns (10th in the NFL) against one interception.
He has racked up 64 rushing yards (21.3 per game) without a touchdown on the ground.
Jordan Mason’s rushing stats this season include 324 yards (second in the NFL) and two touchdowns. He is averaging 108.0 yards per game and 4.8 per attempt (16th in the NFL).
In the passing game, Jauan Jennings has amassed 276 receiving yards (fifth in the NFL) and three touchdowns (first in the NFL) after catching 18 balls (10th in the NFL) on 21 targets. He is averaging 92.0 yards and 6.0 receptions per game in three games.
Deebo Samuel has 13 receptions for 164 yards and zero touchdowns. He has been targeted 19 times in the passing game and is averaging 6.5 receptions and 82.0 yards in two games played.

Defense

On the defensive side, Fred Warner has 20 tackles, 1.0 TFL, one sack and one interception in 2024. His total tackles lead the 49ers.
Nick Bosa has nine tackles, 3.0 TFL and two sacks.
This season, Isaac Yiadom has recorded thirteen tackles.
Charvarius Ward has thirteen tackles to his name so far this season.

New England betting information

New England has posted a 2-1-0 record against the spread this season.
Games involving New England have turned over once this year.
This season, the Patriots have won one of three games in which they were the underdog.
The Patriots have an 18.5% chance of winning this game, based on the implied probability of the moneyline.

Patriots Stats

Stands	Average (total)	Rank
Pass yards	102.0 (306)	32
Urgent yards	144.3 (433)	8
Points scored	13.0 (39)	31
Pass yards against	244.3 (733)	27
Urgent meters against	83.0 (249)	5
Points allowed	19.0 (57)	10

New England’s Key Players

Offence

Rhamondre Stevenson is averaging 74.7 rushing yards per game (224 total yards) this year, while scoring two rushing touchdowns.
Jacoby Brissett has 368 passing yards, one touchdown and zero interceptions. His completion percentage is 60.9% and he is averaging 122.7 yards per game and 5.3 per attempt.
He has also added 38 rushing yards (third among the Patriots), with zero touchdowns on the ground (averaging 12.7 yards per play and 4.2 per carry).
So far this season, Antonio Gibson has amassed 143 rushing yards (second on the Patriots) in three games, but has not scored a rushing touchdown. He averages 47.7 yards per game and 6.2 per attempt (third in the NFL).
Hunter Henry has 12 catches for 136 yards without a receiving touchdown. He is averaging 4.0 yards per game through three games and has been targeted 18 times.

Defense

Keion White’s 2024 showing includes 17 tackles, 3.0 TFL and four sacks in three games. He is second on the Patriots in tackles.
Kyle Dugger has 16 tackles, 3.0 TFL and one sack. He is fourth on the Patriots in tackles.
Jonathan Jones has 18 tackles in the 2024 campaign. He leads the Patriots in tackles.
Jahlani Tavai has 17 tackles, 2.0 TFL and one pass defended.

FOX Sports created this story using technology from Data Skrive and data from Sportradar.

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