Rams offensive tackle Joe Noteboom (70) rides a cart to the locker room after being injured against the Detroit Lions.

(David Dermer/Associated Press)

It’s just one game, but it’s starting to feel like it will be 2022, when the Rams struggled with injuries during their historic Super Bowl victory.

Star receiver Puka Nacua suffered a knee injury in the second half, forcing him out of the game at halftime. Left tackle Joe Noteboom was taken to the locker room with an ankle injury, and left guard Steve Avila did not play in the second half with a knee injury.

Right guard Kevin Dotson left the locker room on crutches and with his left foot and ankle in a protective boot.

Jonah Jackson moved from center to right guard and rookie Beaux Limmer played center. AJ Arcuri, promoted from the practice squad this week, replaced Noteboom at left tackle.

The Rams play the Arizona Cardinals on Sunday.

Left tackle Alaric Jackson remains suspended for one more game, but right tackle Rob Havenstein could return from an ankle injury.

“We’ll see how bad the injuries are for those guys,” coach Sean McVay said, adding: “We’re developing depth, but what we’re not going to do is, we’re not going to allow things to happen, we’re going to learn from the things that happened in previous years … and if guys get injured, then you know what, our job is to get those next guys ready to roll, and that’s exactly what we’ll do.”