The top two players remaining in the men’s rankings at the 2024 US Open will play each other on Wednesday evening.

World No. 1 Jannik Sinner, chasing his second Grand Slam title and first US Open, is a -300 favorite against 2021 champion Daniil Medvedev.

Both players were imperious in their round of 16 victories and have dropped just one set en route to the quarterfinals. In other words, Wednesday’s match should be a blockbuster.

Let’s dive a little deeper into the match and make a choice.

Jannik Sinner vs. Daniil Medvedev odds

Sinner vs. Medvedev Prediction

Sinner entered the 2024 US Open as one of the favorites, but he has also come under scrutiny after it was revealed in March that he had tested positive for a banned substance.

The 2024 Australian Open winner was acquitted by a court, but it was still a moment that shook the sport and put extra pressure on the Italian.

And it looked like the situation was going to get even more dramatic when Sinner lost the first set to Mackenzie McDonald in the first round.

But Sinner recovered from that moment on and won 12 sets in a row, eight of which with at least a four-game lead.

Medvedev also lost a set in his first round, but he has hardly been challenged in this tournament. The Russian has won 10 of his 12 sets by at least three games.

Medvedev also has plenty of positive experience to draw on in this situation. Not only does he have a US Open Trophy on his mantelpiece, but he has also reached the semifinals in four of his last five trips to Queens.

There are also some stylistic touches that the Russian can exploit in this match. Like Sinner, Medvedev is an elite defender who boasts all-world court coverage.

Sinner throws the ball with force, but Medvedev is one of the few players in the world whose defense can match that force.

Check out the best sports betting sites and apps

Sinner has done a great job, but Medvedev has been with him for the past two weeks and will have some tough questions to answer for the world number 1.

This will be a tough task and it underlines the value of Medvedev, who has no problem working late into the New York night.

The Bet: Daniil Medvedev (+230, DraftKings)