Bills storyline to watch: It may only be Week 5, but the Bills defense is already dealing with a variety of challenges, the latest of which this week is Von Miller’s four-game suspension. While middle linebacker Terrel Bernard (pectoral) has a good chance of getting back on the field after missing two games, Buffalo will likely see rookie safety Cole Bishop make his first NFL start – Taylor Rapp is in a concussion protocol – while rookie Javon Solomon will see more of a role in play now that Miller is out. There’s a tough task ahead in the Texans’ offense, with QB CJ Stroud throwing seven passing touchdowns and zero interceptions in his past five home games. — Alaina Getzenberg

Texas storyline to watch: Coach DeMeco Ryans said the Texans are “excited” for this matchup, but said his club does not want to join the storyline of two AFC candidates. The Bills have the third-highest point differential in the NFL (plus-39), while the Texans are 24th (minus-15), showing that the Bills have been more complete through four weeks. The Texans have three wins, but each victory was secured in the final minute after playing sloppily throughout. — DJ Bien-Aime

Statistic to know: If Josh Allen doesn’t throw an interception, this will be the longest streak by a Buffalo quarterback starting a season in franchise history.

Bold prediction: Texans wide receiver Tank Dell has over 85 receiving yards and a touchdown. I’m waiting for the Dell Breakout game and it’s coming soon. The second-year wideout still has a strong open rating of 69 this season, a sign that his decreased production is likely more a product of increased target competition. –Walder

Fantasy X Factor: Texans running back Joe Mixon. Buffalo’s defense is giving up the most fantasy points per game to running backs this season, making it a great fit for Mixon. He has been rehabbing an ankle sprain for a few weeks and there was optimism he could return after practice for Week 4. He was ultimately ruled out, but this match would be perfect for Mixon’s return. — Moody

Bet: Allen is 27-18-2 ATS in his career on the road (13-7-1 ATS as a road underdog).

Kahler’s choice: Texans 27, Bills 21

Moody’s choice: Bills 27, Texans 23

Walder’s choice: Texans 27, Bills 24

FPI prediction: BUF, 56.0% (average 2.2 points)