Veteran nose tackle Michael Pierce, who practiced fully Friday but was downgraded to questionable yesterday due to a shoulder injury, is inactive for the Ravens, leaving them with just four defensive linemen against the Buffalo Bills.

Nnamdi Madubuike, Travis Jones, Broderick Washington and Brent Urban are the team’s only active defensive linemen. The Ravens could move one of their outside linebackers inside if necessary, but it’s still a situation to keep an eye on, especially since Buffalo sometimes uses six offensive linemen to help with a solid running game.

Ravens starting left guard Andrew Vorhees is also inactive for the Ravens. He was questionable for the game due to an ankle injury, but he trained on the field before the game in front of two members of the athletic training staff. With Vorhees sidelined, the Ravens could move right tackle Patrick Mekari to left guard and then insert rookie second-round pick Roger Rosengarten at right tackle.

Also inactive for the Ravens: wide receiver Devontez Walker, center Nick Samac and safety Beau Brade.

Ravens rookie third-round outside linebacker Adisa Isaac, rookie fourth-round cornerback TJ Tampa and second-year guard Malaesala Aumavae-Laulu are active for the first time this season. If they enter the game, all three would be making their NFL debuts.