Aaron Rodgers is no stranger to battling the Minnesota Vikings.

On Sunday, the New York Jets quarterback will start his 30th game against the Vikings, having tied for the most against any opponent. The other team is the Chicago Bears; Rodgers proclaimed he owned them in 2021.

Rodgers has won 17 of his 29 starts, tied with Brett Favre for the most wins by any quarterback against Minnesota. Bart Starr is third on 11.

He has thrown for 7,157 yards, 57 touchdowns and 8 interceptions against the Vikings. In their only playoff game in the 2012 NFC wild card round, Rodgers threw for 274 passing yards and one touchdown in a 24–10 victory.

Rodgers isn’t the first, and likely won’t be the last, signal caller to find significant success against a single opponent.

Here’s a look back at some quarterbacks with regular-season dominance against a single opponent since 2000 (minimum 15 games).

File: 33-3

Win Rate: .917

Brady haunted Bills fans for 20 seasons, making a win against them almost a formality.

His regular-season winning percentage of .917 is the second-best of any quarterback against a single opponent. Only Roger Staubach of the Dallas Cowboys had a better percentage, winning 16-1 (.941) against the New York Giants. Brady’s 33 wins are the most of any quarterback against a single opponent in a regular season; he also ranks second with 30 wins against the Jets.

He threw for 9,032 yards plus 72 touchdowns and 25 interceptions. Brady had perhaps his best performance against Buffalo in 2007, when he threw for 373 yards and five touchdowns in a 56-10 victory.

File: 25-2-1

Win Rate: .911

Big Ben took care of business against the Pittsburgh Steelers division rivals.

He started 10-0 against the Browns, with his first loss coming in a low-scoring affair in 2009. Roethlisberger went on to go undefeated against Cleveland in the regular season for the rest of his career — although the Steelers lost to the Browns in 2020. playoffs 48-37.

File: 13-2

Win Rate: .867

Prescott dropped his first two games to the Giants but hasn’t lost since — a remarkable streak that continued this season.

Prescott’s 13 straight wins against New York are tied for the second-longest winning streak by a quarterback against a single opponent since 1950. Miami’s Bob Griese has the longest winning streak with 17 wins against the Bills.

His best performance came in 2019 when he threw for 405 yards and four touchdowns in a 35-17 win.

Joe Flacco vs. Cleveland Browns

File: 18-3

Win Rate: .857

Before leading them to an improbable run to the 2023 playoffs, Flacco was associated with negative memories for Cleveland fans.

Like Roethlisberger, he had a good start against the Browns, winning his first eleven meetings. Even when he left the AFC North and joined the Jets in 2022, Flacco still haunted Cleveland. He threw for 307 yards and four touchdowns in a win against the Browns in 2022.

File: 17-3

Win Rate: .850

Whether he was with the Indianapolis Colts or Denver Broncos, Manning found success against the Texans.

He threw for 5,853 yards plus a strong 48-to-eight touchdown-to-interception ratio. Manning had two 400-yard passing games, including 433 in 2010 – the sixth-most of his career. After dropping two straight games against the Texans in 2010 and 2012, Manning has won the last eight meetings.

While playing for Houston in 2013, Manning set the single-season record for most touchdowns.

ESPN Research contributed to this story.