The 49ers controlled the first half and took a 20-3 lead into the locker room at halftime. It should have been more, with the 49ers leaving points on the field with two chip shot field goals in the red zone.

The Patriots had just 76 yards in the half, and their only points came on Joey Slye’s 63-yard field goal on the final play of the second quarter. The drive was a four-play drive, minus 6 yards.

San Francisco gained 207 yards and scored on their first three drives, but the first two ended at the New England 3 and 8.

The 49ers scored a touchdown on Fred Warner’s 45-yard pick-six of Jacoby Brissett.

Their first offensive touchdown drive came with 3:11 remaining in the half on an all-time catch by George Kittle, who lofted a perfect pass from Brock Purdy for a 12-yard score. The 49ers had two touchdowns that were negated by penalties earlier in the drive, with Purdy’s 38-yard touchdown pass to Jordan Mason being called back by a holding penalty on Kittle and Purdy’s 7-yard throw to Kyle Juszczyk being called back by an illegal shift.

Purdy is 8 of 15 for 146 yards, while Kittle catches three for 38. Mason has nine carries for 40 yards.

Brissett is 8 of 13 for 54 yards and the pick-six, with Kevin Givens getting 2.5 sacks and Maliek Collins 1.5. Leonard Floyd forced a fumble from Rhamondre Stevenson, his fourth fumble and second lost fumble this season.

The Patriots lost offensive tackle Caedan Wallace (ankle), safety Kyle Dugger (ankle) and center David Andrews (shoulder) in the first half. All three are questionable to return.