Embattled New York City Mayor Eric Adams is facing growing calls from local politicians to resign after he was indicted by a grand jury Wednesday night amid a federal investigation into his mayoral campaign and administration.

Several top members of Adams’ campaign have already resigned amid chaos at City Hall following a series of federal raids on the homes of officials earlier this month, raising concerns about Adams’ ability to lead the Big Apple going forward as he faces legal troubles.

New York City Auditor General Brad Lander said Wednesday was “a sad day for the people of New York” after news of the indictment broke, and that “the most appropriate path forward” is for Adams to step aside.

“Mayor Adams, like all New Yorkers, deserves a fair trial, the presumption of innocence, and his day in court. However, it is clear that defending himself against serious federal charges will take up the significant amount of time and attention needed to govern this great city,” he added.

Lander, who plans to run against Adams in 2025, was one of at least 22 city, state and federal politicians who called on Adams to resign Wednesday night, most of whom are Democratic party members.

Former city controller, Manhattan borough president and mayoral candidate Scott Stringer said the mayor should step down so other leaders can “focus on the business of the city.”

“His fight is not our fight,” Stringer said.

Several City Council members have called for his resignation, including Tiffany Caban (D-Queens), Alexa Aviles (D-Brooklyn), Shekar Krishnan (D-Queens), Lincoln Restler (D-Brooklyn), Chris Banks (D-Brooklyn) and Bob Holden (D-Queens).

“There is no way (Adams) can lead effectively with this cloud hanging over him. Given the challenges facing our city, he must step down for the good of New Yorkers,” said Holden, a moderate.

However, Councilman Oswald Feliz (D-Bronx) told The Post that he is “not there yet” in calling for the mayor to resign.

Councilman Joe Borelli (R-Staten Island) declined to comment on the charges but said he would run for office if the mayor steps down.

New York State Assemblymembers Phara Souffrant Forrest (D-Brooklyn), Emily Gallagher (D-Brooklyn), Danny O’Connell (D-Manhattan), Jessica González-Rojas (D-Queens), Tony Simone (D-Manhattan), Linda Rosenthal (D-Manhattan) and mayoral candidate Zohran Mamdani (D-Queens) have also called for Adams’ ouster.

“Eric Adams must resign. Even before this indictment, he has utterly failed to address the crushing cost of living crisis that is driving working families out of our city. In fact, he has only made it worse,” Mamdani said.

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Senators Julia Salazar (D-Brooklyn), Gustavo Rivera (D-Brooklyn), Jabari Brisport (D-Brooklyn), Zellnor Myrie (D-Brooklyn), Brad Holyman-Sigel (D-Manhattan) and John Liu (D-Queens) also joined the chorus calling for the mayor’s resignation.

U.S. Rep. Alexandria Ocasio Cortez (D-NY) became the highest-ranking Democrat to call on Adams to resign “for the good of the city,” hours before it was announced he had been charged.

Adams is the first sitting mayor of New York City to be indicted.

He has demanded “an immediate trial so the people of New York can hear the truth,” he told The Post.

Adams said he became a target of federal authorities because he stood up for the people of New York and vowed to “fight this with all my might and spirit.”