The Colts entered the weekend having lost every road game against the Jaguars since 2014.

Indianapolis made a valiant effort, but Jacksonville kept that particular streak alive with a 37-34 win.

The Jaguars had a 34-20 lead when Tank Bigsby took a 65-yard carry to the end zone with 5:09 left in the fourth quarter. But led by backup Joe Flacco, the Colts weren’t done yet.

Flacco connected with Alec Pierce for a 46-yard pass to the 1-yard line on the ensuing drive. Trey Sermon went into the end zone on the next play to make the score 34-27 as the Colts didn’t go for two even though they were down by eight.

A quick Jaguars three-and-out gave the Colts the ball back at their own 23. After a run by Sermon, Flacco hit Pierce again, this time for a 65-yard touchdown to tie the score at 34-34.

But as was the case for most of the day, Indianapolis couldn’t make a stop when it needed it most. Quarterback Trevor Lawrence moved Jacksonville into opposing territory with an 11-yard pass to tight end Luke Farrell. Then a 14-yard pass to Christian Kirk put the Jaguars within field goal range.

Rookie Cam Little hit his 49-yard field goal to give the Jaguars a three-point lead with 17 seconds left.

Taavon Walker, who sacked Flacco earlier in the game, finished the game with a sack to win it.

Walker finished the game with five total tackles, including three for loss, with 3.0 sacks, a pass defensed and a forced fumble.

Lawrence set a new career high with 371 passing yards, eclipsing his previous high-water mark of 368. He completed 28 of 34 passes with two touchdowns and an interception.

Rookie Brian Thomas Jr. had five catches for 122 yards, including an 85-yard touchdown in the second quarter.

On the other hand, Flacco finished 34 of 44 with 359 yards with three touchdowns, no picks and a lost fumble. The Colts played without starting quarterback Anthony Richardson, running back Jonathan Taylor and center Ryan Kelly due to injury.

Right guard Will Fries also left the game due to a right leg injury. He was taken off the field with an air throw.

Now sitting at 1-4, the Jaguars will be across the pond next week to play the Bears in London.

The 2-3 Colts will play another AFC South opponent in the Titans.