What you need to know

• Scheduling Note: Immediately after the 49ers play the Rams at SoFi Stadium on Sunday, you can watch “49ers Postgame Live” on NBC Sports Bay Area or stream the show on the NBC Sports app for full reaction, analysis and interviews.
• Both the 49ers (1-1) and Rams (0-2) are dealing with multiple injuries. San Francisco will be without stars Christian McCaffrey, Deebo Samuel and George Kittle, with edge rusher Nick Bosa and cornerback Charvarius Ward questionable. Wide receivers Cooper Kupp and Puka Nacua are the most notable L.A. players who will not play.
• There is good news for the 49ers, as safety Talanoa Hufanga will make his debut in the 2024 season after recovering from a torn ACL. Linebacker Dee Winters will also play for the first time this season.
• With CMC, Samuel and Kittle all on the field, Matt Maiocco identified the five 49ers players to watch against the Rams.